|
Symbol Name ID |
Stim1
stromal interaction molecule 1 MGI:107476 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased circulating IgA level |
Increased circulating IgA level |
Decreased circulating IgG level |
Increased circulating IgG3 level |
Decreased circulating total IgM |
Autoimmune hemolytic anemia |
Abnormal lymphocyte count |
Autoimmune thrombocytopenia |
Lymphadenopathy |
Asplenia |
Hypoplastic spleen |
Splenomegaly |
Recurrent otitis media |
Recurrent urinary tract infections |
Recurrent pneumonia |
Immunodeficiency |
Sepsis |
Recurrent infections |
Recurrent bacterial infections |
| Disease(s) Associated with STIM1 | |||||||||||||||||||
| immunodeficiency 10 | |||||||||||||||||||
| Stormorken syndrome |
| Mouse Phenotypes | immune system phenotype |
decreased B cell proliferation |
decreased mast cell degranulation |
enlarged spleen |
abnormal thrombopoiesis |
increased neutrophil cell number |
decreased NK cell number |
increased lymphocyte cell number |
increased Ly6C high monocyte number |
decreased Ly6C low monocyte number |
increased leukocyte cell number |
abnormal spleen morphology |
increased spleen red pulp amount |
abnormal B cell physiology |
abnormal CD4-positive, alpha-beta T cell physiology |
abnormal lymph node morphology |
enlarged lymph nodes |
decreased susceptibility to type I hypersensitivity reaction |
abnormal cytokine secretion |
abnormal interleukin secretion |
decreased interleukin-10 secretion |
decreased interleukin-13 secretion |
decreased interleukin-2 secretion |
decreased interleukin-6 secretion |
decreased tumor necrosis factor secretion |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||
| Stim1tm1.1Kuro/Stim1tm1.1Kuro | ||||||||||||||||||||||||||
| Stim1em1(IMPC)Mbp/Stim1+ | ||||||||||||||||||||||||||
| Stim1Sax/Stim1+ | * | |||||||||||||||||||||||||
| Stim1tm1.1Kuro/Stim1+ | ||||||||||||||||||||||||||
| Stim1tm1.1Pg/Stim1+ | ||||||||||||||||||||||||||
| Stim1tm1Kuro/Stim1tm1Kuro Cd79atm1(cre)Reth/Cd79a+ (conditional) |
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| Stim1tm1Rao/Stim1tm1Rao Tg(Cd4-cre)1Cwi/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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